HIPAA-Compliant LLM Fine-Tuning: A Practical Guide for Healthcare Leaders
How to safely adapt large language models to PHI without breaking compliance
A step-by-step approach to fine-tuning LLMs on clinical data while staying aligned with HIPAA and your internal AI governance standards.
Published: December 10, 2025
• 7 min read
Why this matters
Many providers are experimenting with LLMs, but very few have a clear path to deploy them on PHI safely.
Key principles
- Identify what data is PHI.
- Apply de-identification and minimization.
- Use HIPAA-eligible infrastructure.
- Embed governance and monitoring from day one.
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